The Quantitative Systems Pharmacology and Toxicology Research Group

News

Brad Reisfeld received the certification of Diplomate, American Board of Toxicology.

Based on work conducted as part of our cooperative agreement with the FDA, Nan-Hung Hsieh published pksensi: an R package for Global Sensitivity Analysis in Pharmacokinetic Modeling.

Vidya Gaddyy and Erica Shin presented a poster entitled “User-Friendly Interface for PBPK Analysis and Simulation” at the Rocky Mountain Celebration of Women in Computing Conference in Lakewood, Colorado.

Ryan Arey gave a seminar in the School of Biomedical Engineering at Colorado State University entitled “A Whole-Body Physiologically-Based Pharmacokinetic (PBPK) Model of the antimalarial drug Artesunate and active metabolite Dihydroartemisinin”.

Brad Reisfeld gave an invited lecture at the Ninth American Conference on Pharmacometrics in San Diego, California entitled “Enhancing the reliability, efficiency, and usability of Bayesian population PBPK modeling”.

The paper, “Applying A Global Sensitivity Analysis Workflow to Improve the Computational Efficiencies in Physiologically-Based Pharmacokinetic Model” by Nan-Hung Hsieh, Brad Reisfeld, Frédéric Bois, and Weihsueh Chiu has now been published in Frontiers in Pharmacology.

“A novel method for the development of environmental public health indicators and benchmark dose estimation using a health-based endpoint for chlorpyrifos” a paper by Todd Zurlinden and Brad Reisfeld was recently published in Environmental Health Perspectives.

Brad Reisfeld developed and chaired a session at the annual meeting of the American Association of Pharmaceutical Scientists focused on the use of Quantitative Systems Pharmacology entitled “Are in silico approaches useful in mitigating and treating drug overdose?”

Renee Lake presented a poster, “Pharm Cat: a physiologic-based pharmacokinetic (PBPK) model to study virtual drug dosing in cats” at the Annual Meeting of the Society of Biomedical Engineering.

Brad Reisfeld, with colleagues Frédéric Bois (INERIS), Weihsueh Chiu (Texas A&M University), Cathie Olschanowsky (Boise State University), and Sudipto Ghosh (Colorado State University), were awarded a grant from the US Food and Drug Administration to support a project entitled “Enhancing the reliability, efficiency, and usability of Bayesian population PBPK modeling”. Funding from this grant will allow the project team to develop an integrated software platform that is expected to lead to more widespread adoption of the pop-PBPK approach and provide scientists with an effective tool to evaluate and improve the efficacy and safety of drugs.

The paper “Characterizing the Effects of Race/Ethnicity on Acetaminophen Pharmacokinetics Using Bayesian Physiologically Based Pharmacokinetic Modeling” by Todd Zurlinden and Brad Reisfeld was selected as a finalist in the best paper competition of the Biological Modeling Specialty Section of the Society of Toxicology.

Todd Zurlinden, a recent Ph.D. graduate of the group and EPA Science to Achieve Results (STAR) Fellowship recipient, is now a post-doctoral fellow at the National Center for Computational Toxicology.

Brad Reisfeld and Arthur Mayeno edited a two-volume book as part of the Humana Press “Methods in Molecular Biology” series entitled “Computational Toxicology”. It is now available from Springer and major bookstores, including amazon.com.

Who We Are

The Quantitative Systems Pharmacology and Toxicology (QSPT) Research Group at Colorado State University is a diverse team of faculty and students that focuses on developing and applying rigorous mathematics, computational tools, and targeted experimentation to study the disposition and effects of toxicants, drugs, and other foreign chemicals on the body.

Through cross-disciplinary collaborations, we also explore linkages between human, animal, and environmental health and work to create technologies to promote wellness across these domains.

More details about the people in our group can be found here.

Contact

If you are interested in joining or collaborating with our group, please contact Brad Reisfeld.