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Biochemical Reaction Network Modeling

Quantitative and Computational Toxicology Research Group


News

Raymond SH Yang is offering a “Physiologically-Based Pharmacokinetic Modeling Workshop for Beginners” at Colorado State University, Fort Collins, Colorado, 04-08 August 2014. See this announcement for more information.

Brad Reisfeld received a Regional Travel Grant from the Fulbright Foundation. With this funding, Dr. Reisfeld will visit the University of New South Wales in Sydney, Australia to explore opportunities for research collaborations and institutional partnerships.

Brad Reisfeld was awarded a US Scholars Grant from the Fulbright Foundation. From June 2013 to May 2014, he will be a Visiting Professor at the Center of Excellence for Environmental Health & Toxicology and the Faculty of Pharmaceutical Sciences at Naresuan University in Phitsanulok, Thailand. During this period, he will be developing and delivering a course, ‘Introduction to Mathematical and Computational Modeling’. He will also be conducting research focused on the development and use of biologically-based models to systematically investigate the disposition of chemicals associated with the cause and treatment of diseases important to the people of Thailand and the surrounding region.

Brad Reisfeld and Arthur Mayeno edited a two-volume book as part of the Humana Press “Methods in Molecular Biology” series entitled “Computational Toxicology”. It is now available from Springer and major bookstores, including amazon.com.

Todd Zurlinden, a graduate student in Brad Reisfeld‘s group, was recently awarded a Science to Achieve Results (STAR) Graduate Student Fellowship from the Environmental Protection Agency. This prestigious award will allow Mr. Zurlinden to pursue research with Dr. Reisfeld in the area of “Environmental Public Health Indicators for Organophosphorus Insecticide Exposure”.


Who We Are

The Quantitative and Computation Toxicology (QCT) Research Group at Colorado State University consists of a multidisciplinary team of scientists with an interest in developing and applying rigorous mathematics, computer-based tools, and targeted experimentation to study the effects of toxicants, drugs, and other foreign chemicals on the body.

Members of the group represent a wide variety of disciplines, including toxicology, pathology, biochemistry, chemistry, physics, veterinary medicine, chemical and biological engineering, and biomedical engineering.

Our current members reside at a number of institutions: Colorado State University (Fort Collins, Colorado), The Hamner Institutes for Health Sciences (Research Triangle Park, North Carolina), and the U.S. Environmental Protection Agency (Research Triangle Park, North Carolina).

Owing to their combination of quantitative skills and biomedical research experience, many of our graduates are highly sought after by academia, industry, and government.

What We Do

There are a number of areas in toxicology of current interest to the group, including studying the toxicities of volatile organic solvents, examining chemically-induced carcinogenesis, developing methodologies for risk assessment, creating techniques for predictive xenobiotic metabolomics, investigating neuro-developmental toxicology and endocrine disruptors, and utilizing state-of-the-art methods to understand toxicological interactions of chemical mixtures.

Research Areas

In general, the focus of research within the group is on developing computational methods and related experimental techniques to study the effects of toxicants, drugs, and other foreign chemicals on the body. Several of the active research areas are listed below.

Xenobiotic Metabolomics
Computational and experimental methods for predicting the metabolite inventory and pathways resulting from xenobiotic exposure.
Carcinogenesis
Research utilizing in vivo, in vitro, and in silico techniques to better understand the complex phenomena involved in chemically-induced carcinogenesis.
Risk Assessment
Research involving a combination of computational approaches and targeted experimentation to understand and predict the risk associated with chemicals and chemical mixtures.
Chemical Mixtures
Research into the multifaceted toxicological interactions that result from exposure to chemical mixtures.
Computational Tools and Modeling Methodologies
Development and validation of computational tools and approaches in computational toxicology.

Contact

If you are interested in joining or collaborating with our group, please contact Brad Reisfeld.