In our toxicological research, we make use of many computational
tools and approaches, several of which are listed below.
- Biochemical Reaction Network Modeling
- Research on an in silico approach that can predict the chemical structures of the metabolites
of one or a mixture of chemicals, generate the metabolic pathways, and interconnect these pathways
through metabolites in common.
- Physiologically Based Pharmacokinetic Modeling
- Research involving a special type of pharmacokinetics
where physiology and anatomy of the animal or human body,
and the biochemistry of the chemical or chemicals of interest,
are incorporated into a conceptual model for computer simulation.
- Clonal Growth Modeling
- Research into how two- and multi-stage carcinogenesis models
can be used to study the way in which cell replication and mutation
influence preneoplastic and neoplastic foci incidence and development.
