QCT Research Group

News

PBPK Modeling Workshop: Dr. Raymond S.H. Yang will be leading a Physiologically-Based Pharmacokinetic Modeling Workshop for Beginners at Colorado State University, August 4-8, 2008. For more information see the course outline. To sign up for the workshop, please visit the registration page.

Dr. Raymond S.H. Yang at EPA NCEA: Under an Intergovernmental Personnel Act (IPA) award to Colorado State University (CSU), Dr. Raymond S.H. Yang is working 50% at the U.S. EPA, National Center for Environmental Assessment (NCEA) Cincinnati Office (NCEA-Cin) with the scientists on the Chemical Mixture Team. Dr. Yang had already spent October and November 2007 at NCEA-Cin and will be going back between March 1 and June 30, 2008. Dr. Yang's major contribution to NCEA-Cin will be on the following projects/initiatives: (1) Organize and teach a workshop on "Physiologically-Based Pharmacokinetic (PBPK) Modeling for Beginngers" in late April and early May, 2008; (2) Work on the project involving Provisional Peer Reviewed Toxicity Values (PPRTV) documents on total petroleum hydrocarbons; (3) Work on the project focused on PBPK modeling of trihalomethanes in pregnant rats; (4) Organize and lead a team-effort of writing a book on "Risk Assessment of Chemical Mixtures"; and (5) Help mentor junior scientists and postdoctoral fellows at NCEA-Cin. This "work rotation" for Dr. Yang between NCEA at Cincinnati and CSU at Fort Collins will go on for at least two years.

New EPA Grant Award: Members of the QCT research group, Dr. Brad Reisfeld, Dr. Raymond S.H. Yang , Dr. Arthur Mayeno, and Dr. Mike Lyons, have been awarded a $748,600 U.S. Environmental Protection Agency (EPA) Science to Achieve Results (STAR) grant to develop a software tool to interpret biomarkers of human exposure to organophosphorus pesticides/insecticides. The project will be carried out in collaboration with researchers at Mississippi State University led by Dr. Janice Chambers.

Who We Are

The Quantitative and Computation Toxicology (QCT) Research Group at Colorado State University consists of a multidisciplinary team of scientists with an interest in developing and applying rigorous mathematics, computer-based tools, and targeted experimentation to study the effects of toxicants, drugs, and other foreign chemicals on the body.

Members of the group represent a wide variety of disciplines, including toxicology, pathology, biochemistry, chemistry, physics, veterinary medicine, chemical and biological engineering, and biomedical engineering.

Our current members reside at a number of institutions: Colorado State University (Fort Collins, Colorado), CIIT Centers for Health Research (Research Triangle Park, North Carolina), and the U.S. Environmental Protection Agency (Research Triangle Park, North Carolina).

What We Do

There are a number of areas in toxicology of current interest to the group, including studying the toxicities of volatile organic solvents, examining chemically-induced carcinogenesis, developing methodologies for risk assessment, creating techniques for predictive xenobiotic metabolomics, investigating neuro-developmental toxicology and endocrine disruptors, and utilizing state-of-the-art methods to understand toxicological interactions of chemical mixtures.