Risk Assessment
Our group has been utilizing a combination of computational approaches (for example,
PBPK modeling and
clonal growth modeling)
and targeted experimentation to understand and predict the risk associated with exposure to
chemicals and
chemical mixtures
. Among other applications, this information has been used to the create a
cumulative risk assessment framework/approach for the US Environmental Protection Agency.
Representative Group Publications:
- Yang, R. S. H., Dennison, J. E., Jr., Lowit, A., and Lipscomb, J. C. Application of PBPK and other biologically-based computer modeling to cumulative risk assessment of chemical mixtures, in Toxicokinetics for Risk Assessment, Ed. J. C. Lipscomb, Dekkar, New York, NY. Submitted for publication.
- Teuschler, L., Klaunig, J., Carney, E., Chambers, J., Connolly, R., Gennings, C., Giesy, J., Hertzberg, R., Klaassen, C., Kodell, R., Paustenbach, D., Yang, R. (2002). Support of science-based decisions concerning the evaluation of the toxicology of mixtures: A new beginning. Regulatory Toxicol. Pharmacol. 36:34-39.
