Chemical Mixtures
We use in vivo (gas uptake chamber studies, modified Ito bioassays),
in vitro (immortalized keratinocyte transformation studies), and
in silico
(PBPK modeling,
clonal growth modeling,
biochemical reaction network modeling
)
techniques to explore the toxicological interactions that result from exposure to
chemical mixtures.
Over the years, our group had looked at the interactions and health risks associated with a wide
variety of chemical mixtures, some of which are included in the following table.
| Class | Examples |
|---|
| chlorinated solvents | trichloroethylene, chloroform |
| polychlorinated biphenyls | PCB126, PCB153 |
| polycyclic aromatic hydrocarbons | benzo[a]pyrene |
| fuel products | gasoline, marine diesel fuel |
| CNS depressents | toluene, ethylbenzene |
| heavy metals | arsenic, methyl mercury |
Representative Group Publications:
- Dennison, J. E., Bigelow, P. L., Mumtaz, M. M., Andersen, M. E., Dobrev, I. D., and Yang, R. S. H. (2005). Evaluation of potential toxicity from co-exposure to three CNS depressants (toluene, ethylbenzene, and xylenes) under resting and working conditions using PBPK modeling. J. Occup. Environ. Health 2:127-135.
- Dennison, J. E., Andersen, M.E., Dobrev, I. D., Mumtaz, M. M., and Yang, R.S.H. (2004). PBPK modeling of complex hydrocarbon mixtures: Gasoline. Environ. Toxicol. Pharmacol. 16:107-119.
- Yang, R. S. H., El-Masri, H. A., Thomas, R. S., Dobrev, I., Dennison, Jr., J. E., Bae, D. S., Campain, J. A., Liao, K. H., Reisfeld, B., Andersen, M. E., Mumtaz, M. M. (2004). Chemical mixture toxicology: from descriptive to mechanistic, and going on to in silico toxicology. Environ. Toxicol. Pharmacol. 18:65-81.
- Dennison, J. E., Andersen, M. E., Clewell, H. J., and Yang, R. S. H. (2004). Development of a PBPK model for volatile fractions of gasoline using chemical lumping analyses. Environ. Sci. Tech. 38:5674-5681.
- Dennison, J. E., Andersen, M.E., and Yang, R.S.H. (2003). Characterization of the pharmacokinetics of gasoline using PBPK modeling with a complex mixture chemical lumping approach. Inhalation Toxicol. 15:961-968.
- Teuschler, L., Klaunig, J., Carney, E., Chambers, J., Connolly, R., Gennings, C., Giesy, J., Hertzberg, R., Klaassen, C., Kodell, R., Paustenbach, D., Yang, R. (2002). Support of science-based decisions concerning the evaluation of the toxicology of mixtures: A new beginning. Regulatory Toxicol. Pharmacol. 36:34-39.
- Klein, M. T., Hou, G., Quann, R., Wei, W., Liao, K. H., Yang, R. S. H., Campain, J. A., Mazurek, M., and Broadbelt, L, J. (2002). BioMOL: A computer-assisted biological modeling tool for complex chemical mixtures and biological processes at the molecular level. Environ. Health Perspect. 110 (Supplement 6):1025-1029.
- Liao, K. H., Dobrev, I., Dennison, Jr., J. E., Andersen, M. E., Reisfeld, B., Reardon, K. F., Campain, J. A., Wei, W., Klein, M. T., Quann, R. J., Yang, R. S. H. (2002). Application of biologically based computer modeling to simple or complex mixtures. Environ. Health Perspect. 110 (Supplement 6):957-963.
- Suk, W. A., Olden, K., and Yang, R. S. H. 2002. Chemical mixtures research: Significance and Future Perspectives. Environ. Health Perspect. 110 (Supplement 6):891-892.
- Dobrev, I., Andersen, M. E., and Yang, R. S. H. (2002). In silico toxicology: Simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane. Environ. Health Perspect. 110:1031-1039.
